Adaptive deep brain stimulation for movement disorders: the long road to clinical therapy. The RNS system: responsive cortical stimulation for the treatment of refractory partial epilepsy. Totally implantable bidirectional neural prostheses: a flexible platform for innovation in neuromodulation. ![]() Proceedings of the Eighth International Workshop on Advances in Electrocorticography. Dynamic network communication as a unifying neural basis for cognition, development, aging, and disease. Deep brain stimulation: current challenges and future directions. This technological approach may be widely applicable to brain disorders treatable by invasive neuromodulation. We validated individual-specific neurophysiological biomarkers during normal daily activities and used those patterns for adaptive deep brain stimulation (DBS). Bilateral four-channel motor cortex and basal ganglia field potentials streamed at home for over 2,600 h were paired with behavioral data from wearable monitors for the neural decoding of states of inadequate or excessive movement. Here, we report the use of an implantable two-way neural interface for wireless, multichannel streaming of field potentials in five individuals with Parkinson’s disease (PD) for up to 15 months after implantation. ![]() Neural recordings using invasive devices in humans can elucidate the circuits underlying brain disorders, but have so far been limited to short recordings from externalized brain leads in a hospital setting or from implanted sensing devices that provide only intermittent, brief streaming of time series data.
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